Summary

Microbes Infect. 2011 Aug;13(8-9):766-70. doi: 10.1016/j.micinf.2011.03.009. Epub 2011 Apr 5.

Selection of HLA-B57-associated Gag A146P mutant by HLA-B∗48:01-restricted Gag140-147-specific CTLs in chronically HIV-1-infected Japanese.

Abstract:

We previously showed the possibility that Gag A146P, which is an escape mutant from HLA-B∗57-restricted CTLs, was selected by HLA-B∗48:01-restricted Gag138-147(LI10)-specific CTLs in a Japanese cohort in which HLA-B∗57 individuals were not detected. We herein demonstrated Gag140-147(GI8) to be the optimal epitope rather than LI10 and that GI8-specific T cells failed to recognize the A146P mutant virus-infected cells. The sequence analysis of Gag146 in 261 chronically HIV-1-infected Japanese showed the accumulation of the A146P mutation in HLA-B∗48:01(+) individuals. These findings together indicate that the A146P mutant is accumulating in Japanese by selection by GI8-specific CTLs.

日本語要旨:

熊本大学エイズ学研究センターとの共同研究で、日本人には存在しないHLA-B57特異的CTLエピトープの逃避変異が、HLA-B48により誘導されていることがわかった。

PMID:  21473930

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