Journal of Japanese Society of Nutrition and Food Science. 68(3):101-111. 2015.

Effect of Short- and Medium-chain Fatty Acid Intake on Cognitive Score Decline over 8 Years among Community-dwelling Elderly


Summary: To clarify any associations of short- and medium-chain fatty acid intake with cognitive decline, we studied 298 men and 272 women aged 60 years and older at the baseline who participated at least once in the follow-up study of the National Institute for Longevity Sciences - Longitudinal Study of Aging. Cognitive function was assessed using the Mini-Mental State Examination (MMSE). Nutritional intake was assessed using a 3-day dietary record. Cumulative data for participants with an MMSE score of >27 in the second wave (baseline) were analyzed using a generalized estimation equation. Multivariate-adjusted odds ratios (OR) and 95% confidence intervals (CI) for an MMSE score of <= 27 (cognitive score decline) in each study wave according to a 1 standard deviation (SD) increase of short-, medium-, and long-chain fatty acid intake at the baseline were estimated after adjusting for sex, age, follow-up time and other covariates. The multivariate-adjusted OR for a decline in MMSE score (<=27) was 0.86 (95%CI: 0.75-0.98) with a 1-SD increase intake of short-chain fatty acids (181 mg/day), 0.84 (0.74-0.95) for medium-chain fatty acids (232 mg/day), and 0.89 (0.76-1.04) for long-chain fatty acids. Short- and medium-chain fatty acid intake may prevent cognitive score decline in community-dwelling elderly.