Abstract:

We investigated the plasma levels of VEGF and FGF-2, important factors for regulation of neuroplasticity such as neurogenesis, in patients in remission from major depressive disorders (MDD). The plasma VEGF levels were significantly higher in the MDD patients than in the matched control subjects, while no significant difference in plasma FGF-2 levels was found. In particular, the MDD patients with family history of psychiatric disorders, but not patients without such a family history, showed significantly higher values of plasma VEGF than the controls. Although this is a preliminary study, altered VEGF levels might be involved in the pathophysiology of MDD.

日本語要旨:

大うつ病の寛解期にある患者において、神経発生に関係の深いVEGFとFGF-2の血中レベルの検討を行った。FGF-2は正常者と差はなかったが、VEGFは明かなさを認め、特に家族歴を有する患者で高値を示した。