Summary

Brain Dev. 2011 May;33(5):390-3. doi: 10.1016/j.braindev.2010.08.011. Epub 2010 Sep 9.

Absence of small-vessel abnormalities in alternating hemiplegia of childhood.

Abstract:

OBJECTIVE: To investigate whether Japanese patients with alternating hemiplegia of childhood (AHC) have the similar small-vessel abnormalities in skin reported in European patients with AHC.
METHODS: Electron microscopic observation of biopsied skin specimens were carried out in six Japanese patients with AHC. All patients (aged 5-17, all boys) had been diagnosed with AHC through their typical clinical courses and symptoms.
RESULTS: No abnormal findings in both endothelial cells and smooth muscle cells in skin small-vessels were obtained in the present study, either in the five flunarizine responders or in the one non-responder.
CONCLUSIONS: From our observations, we hypothesized that there may be some subtypes of AHC. The diverse clinical courses in patients with AHC and the differing efficacy of flunarizine treatment could be explained because of the heterogeneity of AHC subtypes.

日本語要旨:

小児交互性片麻痺の微小血管異常の有無を電顕を用いて病理学的に検討したが、異常を見出し得なかった。

PMID:  20826074

前ページへ戻る

PAGE TOP