Arch Neurol. 2012 Jun;69(6):728-32. doi: 10.1001/archneurol.2011.1728.

Myopathy associated with antibodies to signal recognition particle: disease progression and neurological outcome.


OBJECTIVE: To characterize the clinical course of myopathy associated with antibodies to signal recognition particle (SRP), or anti-SRP myopathy.
DESIGN: Case series.
SETTING: Keio University Hospitals and National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.
PATIENTS: We reviewed clinical features of 27 patients with anti-SRP myopathy and analyzed disease progression and neurological outcome.
MAIN OUTCOME MEASURES: Anti-SRP antibodies in serum were detected by RNA immunoprecipitation assay using extracts of K562 cells.
RESULTS: Of the 27 patients, 5 (19%) showed chronic progressive muscle weakness as well as atrophy of limbs and trunk muscles from a younger age with more severe neurological outcomes compared with the other 22 patients(81%) with the subacute form.
CONCLUSION: A subset of patients with anti-SRP myopathy can show a chronic progressive form associated with severe clinical deficits.



PMID:  22332183