Summary

J Acquir Immune Defic Syndr. 2014 Aug 15;66(5):484-6. doi: 10.1097/QAI.0000000000000222.

Low raltegravir concentration in cerebrospinal fluid in patients with ABCG2 genetic variants.

Abstract:

Adenosine triphosphate-binding cassette transporter G2 (ABCG2) is expressed on the cerebrospinal fluid (CSF) side of choroid plexus epithelial cells, which form the blood-CSF barrier. Raltegravir was recently identified as a substrate of ABCG2. In the present study, we analyzed the relationship between single-nucleotide polymorphisms of ABCB1 and ABCG2 genes and raltegravir concentrations in 31 plasma and 14 CSF samples of HIV-infected patients treated with raltegravir-containing regimens. The mean CSF raltegravir concentration was significantly lower in CA (25.5 ng/mL) and AA (<10 ng/mL) genotypes at position 421 in ABCG2 gene compared with CC (103.6 ng/mL) genotype holders (P = 0.016).

日本語要旨:

髄液中のraltegravir濃度が極めて低くなるABCG2遺伝子多型を発見した。

PMID:  24872134

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