Summary

Nutrients. 2018 Nov 3;10(11). pii: E1655. doi: 10.3390/nu10111655.

Longitudinal Association between n-3 Long-Chain Polyunsaturated Fatty Acid Intake and Depressive Symptoms: A Population-Based Cohort Study in Japan.

Abstract:

It remains unclear whether n-3 long-chain polyunsaturated fatty acids (LCPUFA) have a preventive effect on depression in the general population. This study investigated the longitudinal association between n-3 LCPUFA intake and depressive symptoms in community-dwelling Japanese participants. The participants were aged 40⁻79 years at baseline in the cohort study; wherein examinations; including the assessment of depressive symptoms and nutritional status; were biennially conducted from 1997 to 2012. The subjects (n = 2335) who had a Center
for Epidemiologic Studies Depression Scale (CES-D) score < 16 at the first examination and who participated in the follow-up study at least once were included in the analysis. The follow-up end point was the first onset (CES-D ≥ 16) or the last examination participation. Hazard ratios (95% CIs) for CES-D ≥ 16 were estimated using the adjusted Cox proportional hazards model. Overall; 22.1%
participants showed depressive symptoms during follow-up (average; 8.1 years). Compared with the lowest tertile; the highest HR for EPA was 0.74 (0.60⁻0.93), and highest and middle HRs for DHA were 0.79 (0.63⁻0.98) and 0.80 (0.65⁻0.99) (P
for trend = 0.009 and 0.032), respectively. Among populations with high fish consumption; higher n-3 LCPUFA intake may be associated with a low risk of depressive symptoms.

日本語要旨:

日本の地域在住中高年者を対象とした縦断解析により、n-3長鎖不飽和脂肪酸の摂取が抑うつ傾向リスクを低下させる可能性を示した。

PMID:  30400311

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